By 5312 he was a Guild Captain. A disease broke out from Yasefe and the D'ni people fled the City. Following the example of former Guild Master Jaysem, he decided to stay in his class studying until the illness is cured. King Me'emen invited him to the palace, and when he saw his determination, he gave Irem anything he needed. Irem spent four days and nights without sleeping and on the fifth day, the cure was found.
Irem was appointed Grand Master by the King while the previous, Shemef, was expelled. He also ordered that his story be taught to all the students of the Guild as a reminded of the power of D'ni, their medicines and learning.